Publications
Stereodivergent Union of Esters and Dienes via Cooperative Lewis Base/Palladium Catalysis
Eric R. Dobias, T. N. Snaddon*
Chem. 2022, 8, 2574–2575.
Structure-specific Amyloid Precipitation in Biofluids
M. Rodrigues, P. Bhattacharjee, A. Brinkmalm, D. T. Do, C. M. Pearson, S. De, A. Ponjavic, J. A. Varela, K. Kulenkampff, I. Baudrexel, D. Emin, F. S. Ruggeri, J. E. Lee, A. R. Carr, T. P. J. Knowles, H. Zetterberg, T. N. Snaddon*, S. Gandhi*, S. F. Lee*, D. Klenerman*
Nat. Chem. 2022, 14, 1045–1053.
A Pd–H/Isothiourea Cooperative Catalysis Approach to anti-Aldol Motifs: Enantioselective α-Alkylation of Esters with Oxyallenes
H.-C. Lin, G. J. Knox, C. M. Pearson, C. Yang, V. Carta, T. N. Snaddon*
Angew. Chem. Int. Ed. 2022, 61, e202201753
A Comparative Study of High-Contrast Fluorescence Lifetime Probes for Imaging Amyloid in Tissue
F. Gorka, S. Daly, C. M. Pearson, E. Bulovaite, A. Handa, S. G. N. Grant, T. N. Snaddon*, L.-M. Needham*, S. F. Lee*
J. Phys. Chem. B 2021, 125, 13710–13717.
A Comparative Photophysical Study of Structural Modifications of Thioflavin T-Inspired Fluorophores
L.-M. Needham, J. Weber, C. M. Pearson, D. T. Do, F. Gorka, G. Lyu, S. E. Bohndiek, T. N. Snaddon* and S. F. Lee*
J. Phys. Chem. Lett. 2020, 11, 8406–8416.
Enantioselective Syntheses of Strychnos and Chelidonium Alkaloids via Regio- and Stereocontrolled Cooperative Catalysis
L. Hutchings-Goetz, C. Yang, J. W. B. Fyfe and T. N. Snaddon*
Angew. Chem. Int. Ed. 2020, 59, 17556–17564.-
Highlighted in Trends in Chemistry: "Cooperative Activation Modes for Catalysis-based Total Synthesis" Trends Chem. 2020, 2, 959–961
ThX – A Superior Amyloid Probe for the Early Detection of Amyloid Aggregates
L.-M. Needham, J. Weber, J. A. Varela, J. W. B. Fyfe, D. T. Do, C. K. Xu, L. Tutton, R. Cliffe, B. Keenlyside, D. Klenerman, C. M. Dobson, C. A. Hunter, K. H. Müller, K. O’Holleran, S. E. Bohndiek, T. N. Snaddon* and S. F. Lee*
Chem. Sci. 2020, 11, 4578–4583.
Tertiary Amine Lewis Base Catalysis in Combination with Transition Metal Catalysis
G. J. Knox, L. Hutchings-Goetz, C. M. Pearson and T. N. Snaddon
Tertiary Amine Lewis Base Catalysis in Combination with Transition Metal Catalysis in Asymmetric Organocatalysis Combined with Metal Catalysis: B. A. Arndtsen and L.-Z. Gong Eds.
Topics in Current Chemistry 2020, 378, 99–130
A Modular Construction of Epidithiodiketopiperazines
Thomas N. Snaddon,* Toya D. Scaggs, Colin M. Pearson, and James W. B. Fyfe.
Org. Lett. 2019, 21, 4873–4877.
A Regio‐ and Stereodivergent Synthesis of Homoallylic Amines by a One‐Pot Cooperative‐Catalysis‐Based Allylic Alkylation/Hofmann Rearrangement Strategy
Colin M. Pearson, J. W. B. Fyfe and T. N. Snaddon*
Angew. Chem. Int. Ed. 2019, 58, 10521–10527.
An enantioselective synthesis of α-alkylated pyrroles via cooperative isothiourea/palladium catalysis
Org. Biomol. Chem. 2019, 17, 1787.
Enantioselective α-Allylation of Aryl Acetic Acid Esters via C1-Ammonium Enolate Nucleophiles: Identification of a Broadly Effective Palladium Catalyst for Electron-Deficient Electrophiles.
Luke Hutchings-Goetz, Chao Yang, and Thomas N. Snaddon*
ACS Catal. 2018, 8, 10537–10544
Enantioselective α‐Benzylation of Acyclic Esters Using π‐Extended Electrophiles
Kevin J. Schwarz, Chao Yang, James W.B. Fyfe, Thomas N. Snaddon*
Angew. Chem. Int. Ed, 2018, 57, 12102 –12105.
Enantioselective α‐Allylation of Acyclic Esters using B(pin)‐Substituted Electrophiles: Independent Regulation of Stereocontrol Elements via Cooperative Pd/Lewis Base Catalysis
W. Rush Scaggs, Thomas N. Snaddon*
Chemistry: A European Journal, 2018, 24, 14378 –14381.
Traversing Steric Limitations via Cooperative Lewis Base/Pd Catalysis: An Enantioselective Synthesis of α‐Branched Esters using 2‐Substituted Electrophiles
Kevin J. Schwarz, Colin M. Pearson, Gabriel A. Cintron-Rosado, Peng Liu,* Thomas N. Snaddon*
Angew. Chem. Int. Ed. 2018, 57,7800 –7803Highlighted in Synfacts.
Si-directed regiocontrol in asymmetric Pd-catalyzed allylic alkylations using C1-ammonium enolate nucleophiles
James W.B. Fyfe, Omaru M. Kabia, Colin M. Pearson, Thomas N. Snaddon*
Tetrahedron, 2018, 74, 5383–5391.
Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species
Lisa-Maria Needham, Judith Weber, James W.B. Fyfe, Omaru M. Kabia, Dung T. Do, Ewa Klimont, Yu Zhang, Margarida Rodrigues, Christopher M. Dobson, Sonia Ghandi, Sarah E. Bohndiek,* Thomas N. Snaddon,* Steven F. Lee*
R. Soc. open sci. 5, 171399
Alkene Photo-Isomerization Inspired by Vision
Colin M. Pearson and Thomas N. Snaddon
ACS Cent. Sci. 2017, 3(9), 922
Uniting C1-Ammonium Enolates and Transition Metal Electrophiles via Cooperative Catalysis: The Direct Asymmetric α-Allylation of Aryl Acetic Acid Esters
Kevin J. Schwarz, Jessica L. Amos, J. Cullen Klein, Dung T. Do, and Thomas N. Snaddon*
J. Am. Chem. Soc. 2016, 138, 5214–5217
Callipeltosides A, B and C: Total Syntheses and Structural Confirmation
J. R. Frost; C. M. Pearson; T. N. Snaddon; R. A. Booth; R. M. Turner; J. Gold; D. M. Shaw; M. J. Gaunt; S. V. Ley Chem. Eur. J. 2015, 21, 13261-13277
Highlights from the 47th EUCHEM conference on stereochemistry, Bürgenstock, Switzerland, May 2012
T. D. Sheppard and T. N. Snaddon Chem. Commun. 2012, 48, 11597-11600
Convergent Total Syntheses of Callipeltosides A, B and C
J. R. Frost; C. M. Pearson; T. N. Snaddon; R. Booth; S. V. Ley Angew. Chem., Int. Ed. 2012, 51, 9366-9371
A Synthesis of the Pseudopterosin A-F Aglycone
J. P. Cooksey; P. J. Kocienski; A. W. Schmidt; T. N. Snaddon; C. A. Kilner Synthesis 2012, 44, 2779-2785
A Formal Synthesis of Ionomycin
Z. Gao; Y. Li; J. P. Cooksey; T. N. Snaddon; S. Schunk; E. M. E. Viseux; S. M. McAteer; P. J. Kocienski Synthesis 2011, 104-108.
The Total Synthesis of Berkelic Acid
T. N. Snaddon; P. Buchgraber; S. Schulthoff; C. Wirtz; R. Mynott; A. Fürstner Chem. Eur. J. 2010, 16, 12133-12140.
Synthesis of an Ionomycin Calcium Complex
Z. Gao; Y. Li; J. Cooksey, T. N. Snaddon; S. Schunk; E. Viseux; S. McAteer; P. J. Kocienski Angew. Chem., Int. Ed. 2009, 48, 5022-5025.
A Synthesis-Driven Structure Revision of Berkelic Acid Methyl Ester
P. Buchgraber; T. N. Snaddon; C. Wirtz; R. Mynott; R. Goddard; A. Fürstner Angew. Chem., Int. Ed. 2008, 47, 8450-8454.
Preparation of a 1-Alkoxy-1-alkyne From Reaction of a 2,2,2-Trifluoromethyl Ether With an Alkyllithium Reagent: 1-Benzyloxymethoxy-1-hexyne
P. J. Kocienski; T. N. Snaddon Org. Synth. 2008, 85, 45-52.
Synthesis of the C1-C16 Fragment of Ionomycin Using a Neutral (η3-Allyl)iron Complex
J. Cooksey; P. J. Kocienski; Y. Li; S. Schunk; T. N. Snaddon Org. Biomol. Chem. 2006, 4, 3325-3336.
Direct Conversion of N-Methoxy-N-methylamides (Weinreb amides) to Ketones via a Novel Non-classical Wittig Reaction
J. A. Murphy; A. G. C. Commeureuc; T. N. Snaddon; T. M. McGuire; T. A. Khan; K. Hisler; M. L. Dewis; R. Carling Org. Lett. 2005, 7, 1427-1429.
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